A Flexible Parylene Neural Probe Combined with a Microdialysis Membrane
نویسندگان
چکیده
We designed a flexible probe to record both neuroelectrical and neurochemical activities (Figure 1). This probe has four microelectrodes for neural recording and a fluidic channel covered with a semipermeable membrane; the membrane is used for microdialysis in the brain. We measured impedance of the electrodes, and examined the leakage of dialysate from the fluidic channel in vitro.
منابع مشابه
Design and Microfabrication Considerations for Reliable Flexible Intracortical Implants
Current microelectrodes designed to record chronic neural activity suffer from recording instabilities due to the modulus mismatch between the electrode materials and the brain. We sought to address this by microfabricating a novel flexible neural probe. Our probe was fabricated from parylene-C with a tungsten–titanium alloy metal, using contact photolithography and reactive-ion etching, with t...
متن کاملNovel flexible Parylene neural probe with 3D sheath structure for enhancing tissue integration.
A Parylene C neural probe with a three dimensional sheath structure was designed, fabricated, and characterized. Multiple platinum (Pt) electrodes for recording neural signals were fabricated on both inner and outer surfaces of the sheath structure. Thermoforming of Parylene was used to create the three dimensional sheath structures from flat surface micromachined microchannels using solid micr...
متن کاملA Novel Flexible Sinusoidal Probe for Chronic Extracellular Brain Recording
Current microelectrodes designed to record chronic neural activity suffer from recording instabilities due to the modulus mismatch between the electrode materials and the brain. We sought to address this by microfabricating a novel flexible neural probe. Our probe was fabricated from parylene-C with a WTi metal, using contact photolithography and reactive ion etching, with three design features...
متن کاملElectron-beam lithography for polymer bioMEMS with submicron features
We present a method for submicron fabrication of flexible, thin-film structures fully encapsulated in biocompatible polymer poly (chloro-p-xylylene) (Parylene C) that improves feature size and resolution by an order of magnitude compared with prior work. We achieved critical dimensions as small as 250 nm by adapting electron beam lithography for use on vapor deposited Parylene-coated substrates...
متن کاملA Neurospheroid Cultured on the Tip of a Flexible Microelectrode for Cortical Microstimulation
This paper describes a flexible microelectrode combined with a neuronal spheroid (neurospheroid) cultured on the electrode tip. Prior works have found that neurons of a neurospheroid can extend their axons to form synaptic connections with neurons inside living neuronal tissues, that could enable such tissues to be stimulated via transplanted neurons (i.e., instead of through the insertion of i...
متن کامل